CompositionDivalproex (500 mg) SALT INFORMATIONDivalproex (500 mg) TYPICAL USAGE epilepsy, migraine SIDE EFFECTS Thrombocytopenia, leucopenia, bone marrow depression, headache, weight gain, edema. DRUG INTERACTION Divalproex is known to interact with other drugs like mephenytoin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Divalproex sodium dissociates to the valproate ion in the GI tract and increases brain concentrations of GABA which may also play an important role in the prevention of migraine attacks.