CompositionCefuroxime (500mg),Clavulanic Acid (125mg) SALT INFORMATIONCefuroxime (500mg) TYPICAL USAGE Respiratory tract infections. Uncomplicated gonorrhoea. Otitis media. Meningitis, Prophylaxis of surgical infections. Susceptible infections. SIDE EFFECTS Pseudomembranous colitis, urticaria, thrombocytopenia, hemolytic anemia, skin rashes, serum sickness, hypersensitivity reactions, nausea, vomiting, diarrhea, urticaria, pruritus, jaundice, skin rash, pseudomembranous colitis, elevation of liver enzymes, drug fever. DRUG INTERACTION Cefuroxime is known to interact with other drugs like probenecid. MECHANISM OF ACTION Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins, it is possible that cefuroxime interferes with an autolysin inhibitor. Clavulanic Acid (125mg) TYPICAL USAGE Bacterial infections, myeloablative therapy followed by bone marrow transplantation, respiratory tract infections, urinary tract infection. SIDE EFFECTS Hypersensitivity reactions, eosinophilia, severe diarrhea, hepatic cholestasis, nausea, vomiting, diarrhea, fever, maculopapular rash, urticaria, increase in serum transaminase. DRUG INTERACTION Clavulanic acid is known to interact with other drugs like demeclocycline, doxycycline, ethinyl estradiol, mestranol, methotrexate, tetracycline. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Clavulanic acid competitively and irreversibly inhibits a wide variety of beta-lactamases. Binding and irreversibly inhibiting the beta-lactamase results in a restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria. By inactivating beta-lactamase (the bacterial resistance protein), the accompanying penicillin/cephalosporin drugs may be made more potent as well.