CompositionCalcitriol (0.25 mcg),Zinc (7.5 mg),Calcium Carbonate (500 mg) SALT INFORMATIONCalcitriol (0.25 mcg) TYPICAL USAGE Managing hypocalcemia in patients undergoing dialysia for chronic renal failure. Renal osteodystrophy. Hypocalaemia and Hyperphosphataemia. Vitamin D dependent rickets, renal tubular osteomalacia. SIDE EFFECTS Nausea, stomach upset, skin rash, acute toxicity. DRUG INTERACTION Hypermagnesaemia may develop in patients on chronic renal dialysis. Hypercalcaemia in patients on digitalis may precipitate cardiac arrhythmias. MECHANISM OF ACTION Calcitriol promotes calcium absorption in the intestines and retention at the kidneys thus increasing serum calcium levels. It also increases renal tubule phosphate resorption consequently decreasing serum phosphatase levels, PTH levels and bone resorption. Zinc (7.5 mg) TYPICAL USAGE Zinc is used for treatment and prevention of zinc deficiency and its consequences, including stunted growth and acute diarrhea in children, and slow wound healing. It is also used for boosting the immune system, treating the common cold and recurrent ear infections, and preventing lower respiratory infections. It is also used for malaria and other diseases caused by parasites. Zinc is also used for an eye disease called macular degeneration, for night blindness, and for cataracts. It is also used for asthma; diabetes; high blood pressure; acquired immunodeficiency syndrome (AIDS); and skin conditions such as psoriasis, eczema, and acne. SIDE EFFECTS Taking high amounts of zinc is likely unsafe. High doses above the recommended amounts might cause fever, coughing, stomach pain, fatigue, and many other problems. DRUG INTERACTION Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval. MECHANISM OF ACTION Zinc is needed for the proper growth and maintenance of the human body. It is found in several systems and biological reactions, and it is needed for immune function, wound healing, blood clotting, thyroid function. Zinc plays a key role in maintaining vision, and it is present in high concentrations in the eye. Zinc deficiency can alter vision, and severe deficiency can cause changes in the retina (the back of the eye where an image is focused). Calcium Carbonate (500 mg) TYPICAL USAGE Flatulence, Heart burn, Hypocalcaemia, Peptic ulcer, Upset stomach, and can also be given in adjunctive therapy as an alternative drug of choice in Hyperphosphataemia, Renal failure. SIDE EFFECTS Constipation, flatulence; hypercalcaemia; metabolic alkalosis. DRUG INTERACTION Co-administration with thiazide diuretics or vit D may lead to milk-alkali syndrome and hypercalcaemia. MECHANISM OF ACTION Calcium carbonate can neutralise gastric acid rapidly and effectively. However, it may adversely activate Ca dependent processes, leading to secretion of gastric and hydrochloric acid. It can induce rebound acid secretion and, prolonged high doses may cause hypercalcemia, alkalosis and milk-alkali syndrome.